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Dr. Dan KueblerMay 18, 20221 min read

Analysis of Lifespan by David Sinclair [VIDEOS]

Dr. David Sinclair has done groundbreaking research on what happens in aging cells and how to slow down some of these cellular aging processes. 

In the videos below, Dr. Dan Kuebler gives a brief summary of the science described in Sinclair’s book, Lifespan, which contains a few primary arguments surrounding aging.

The Survival Circuit According to David Sinclair

Dr. Sinclair explains that organisms tend to be either in a state of growth or a state of repair. Growth happens when organisms have all the resources they need to survive, such as plentiful food and water. During times of scarcity, however, cells will shift into “repair” mode, where they focus on maintaining health rather than growing. Dr. Sinclair argues that more time spent in repair mode can increase longevity.

David Sinclair on Aging as Damage to DNA

Sirtuins are proteins that help maintain epigenetic order in cells, or in other words, they ensure that the correct genes are being “turned on and off” for the appropriate cellular functions. As damage occurs to the DNA, the sirtuins are used to facilitate repair, which then limits their ability to maintain the epigenetic order of the cells. Dr. Sinclair’s research has indicated that it may be possible to reduce aging by regulating the sirtuins to increase their ability to maintain cellular order and functioning.

Is Aging Necessary? Two Scientists' Opinions

Dr. Sinclair argues that it may not be. Watch to hear Dr. Kuebler’s perspective as well.


Dr. Dan Kuebler

Dr. Dan Kuebler is a Professor of Biology at the Franciscan University of Steubenville. He holds a Ph.D. in Molecular and Cell Biology from UC Berkeley and is co-author of The Evolution Controversy, A Survey of Competing Theories.